Volume 22
Number 3
Sep 2015
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Case Reports
S. Popal, B.W. Verbaan, G.C.M. Vreeburg, B.P. Ramakers

Antithyroid drug-induced neutropenia is a rare and potentially life-threatening complication with an incidence of agranulocytosis ranging from 1-5 cases per million per year. Here we report a case of a 57-year-old female with septic
shock due to necrotising laryngitis and epiglottitis as a result of methimazole-induced agranulocytosis. She was treated with antibiotics, granulocyte colony-stimulating factor, and radiological and surgical abscess drainage during a 24-day stay in the ICU. This case underlines once more the importance of patient education with the use of antithyroid drugs.

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